We are constantly adding the most up-to-date results of clinical trials and double-blind studies from around the world.
Following is a partial list of international clinical trials conducted on high OPC pine bark extract. For more detailed information (including PDF files) regarding these studies, please email info@biopurohealth.com.
01. Enzogenol® For Cognitive Functioning in Traumatic Brain Injury: A Pilot Placebo-Controlled rct.
Theodom, A., Mahon, S., Barker-Collo, S., McPherson, K., Rush, E., Vandal, A.C., Feigin, V.L., European Journal of Neurology, 2013 Feb 5.
02. Production, Composition and Toxicology Studies of Enzogenol® Pinus Radiata Bark Extract
Frevel, M. A., Pipingas, A., Grigsby, W. J., Frampton, C. M., Gilchrist, N. L., 2012. Food and Chemical Toxicology 50, 4316-4324.
03.Attenuated Tumor Necrosis Factor-alpha-Induced Endothelial Cell Adhesion and Monocyte Transmigration
Kim, D. S.; Kim, M. S.; Kang, S. W.; Sung, H. Y.; Kang, Y. H. Pine Bark Extract Enzogenol Attenuated Tumor Necrosis Factor-alpha-Induced Endothelial Cell Adhesion and Monocyte Transmigration. J Agric Food Chem 58: 7088; 2010.
04. Improved Cognitive Performance After Dietary Supplementation with a Pinus Radiata Bark Extract Formulation
Pipingas, A.; Silberstein, R. B.; Vitetta, L.; Rooy, C. V.; Harris, E. V.; Young, J. M., et al. Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract Formulation. Phytotherapy Research 22:9 p1168-1174; 2008.
05.Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication.
Chayasirisobhon, S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache 46: 788-793; 2006.
06. Comparative effects of pine bark extract and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers.
Young, J. M.; Shand, B. I.; Mcgregor, P. M.; Scott, R. S.; Frampton, C. M. Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radic Res 40: 85-94; 2006.
07.Pilot study on the clinical effects of dietary supplementation with a flavonoid extract of pine bark and vitamin C.
Shand, B.; Strey, C.; Scott, R.; Morrison, Z.; Gieseg, S. Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C. Phytother Res 17: 490-494; 2003.
08. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects.
Senthilmohan, S. T.; Zhang, J.; Stanley, R. A. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutrition Research 23: 1199-1210; 2003.
09.Antioxidant activity of procyanidin-containing plant extracts at different pHs.
Wood, J. E.; Senthilmohan, S. T.; Peskin, A. V. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77: 155-161; 2002.